Status and implementation of the MXCuBE experiment control and ISPyB information system at the P11 macromolecular crystallography beamline at PETRA III (DESY, Hamburg)
Abstract The P11 beamline at PETRA III (DESY, Hamburg) is a versatile instrument dedicated to High Throughput Macromolecular Crystallography. The combination of the Eiger detector and sample changer robot allows data collection in about two minutes per sample. MXCuBE is used as a standard data acquisition software at several synchrotron beamlines, including the beamlines P13 and P14 operated by the European Molecular Biology Laboratory (EMBL) at PETRA III. A unified interface at various MX beamlines improves the cross-facility user experience and the convenience of conducting experiments. This work describes the current status and challenges of implementing MXCuBE and ISPyB as standard data collection and representation interfaces at the P11 beamline. In particular, we address the unique, in-house designed hardware of the beamline. This work has been jointly carried out by DESY and EMBL staff to harmonize the data acquisition interfaces at the Macromolecular Crystallography beamlines at the PETRA III storage ring in Hamburg.
Authors
- Frank Schluenzen (ORCID: https://orcid.org/0000-0003-2849-0542)
- André Rothkirch
- Maria P. Nikolova (ORCID: https://orcid.org/0000-0002-0597-7799)
- G. Bourenkov
- T. Schneider (ORCID: https://orcid.org/0000-0001-6955-7374)
- G. Pompidor
- Ivars Karpičs (ORCID: https://orcid.org/0000-0002-3042-9268)
- Vicente Rey‐Bakaikoa (ORCID: https://orcid.org/0000-0003-2987-6391)
- M. Agthe (ORCID: https://orcid.org/0000-0002-2068-6201)
- H. Taberman
- Jochen Meyer
- Samuel Flewett (ORCID: https://orcid.org/0000-0002-8020-872X)
- Selina L. S. Storm (ORCID: https://orcid.org/0000-0001-9223-5576)
- C. Borges
- J. Hakanpää
- A. Gruzinov
- Jia L. Song (ORCID: https://orcid.org/0000-0002-5664-1136)
- Martin Savko (ORCID: https://orcid.org/0000-0001-8481-1203)
- Thomas A. White (ORCID: https://orcid.org/0000-0002-8407-0270)
- S. Chatziefthymiou
- V. Delsoglio
- A. Grebentsov
- O. Merkulova
- S. N. Potturu
- T. Melson
Institutions
- Universität Hamburg (DE)
- Synchrotron soleil (FR)
- Deutsches Elektronen-Synchrotron DESY (DE)
- European Synchrotron Radiation Facility (FR)
- HAW Hamburg (DE)
- European X-Ray Free-Electron Laser (DE)
Publication Details
- Journal
- Journal of Physics Conference Series
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1088/1742-6596/3010/1/012139
- Primary Topic
- Enzyme Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00