Accuracy of the newly manufactured multiplex XGEN MASTER LEPRAE molecular kit and the point-of-care Bioclin FAST ML FLOW test for case definition and early diagnosis of leprosy among household contacts
This study demonstrated the ability of both the PoC-ML-FLOW and XGEN tests, along with clinical exams, to diagnose leprosy among HHCs. The use of the XGEN test in the definition of leprosy cases demonstrated a specificity of 100%, with a significant increase in sensitivity when associated with slit-skin smears.
Authors
- George Jó Bezerra Sousa (ORCID: https://orcid.org/0000-0003-0291-6613)
- Ciro Martins Gomes (ORCID: https://orcid.org/0000-0002-3069-6884)
- Jurema Guerrieri Brandão
- Alexandre Casimiro de Macedo (ORCID: https://orcid.org/0000-0002-9965-5757)
- Patrícia Pereira Lima Barbosa (ORCID: https://orcid.org/0000-0003-2863-0787)
- Patrícia Estrela Evangelista
- Thiago Brobio Massanti
Institutions
- Universidade de Brasília (BR)
- Hyundai Mobis (South Korea) (KR)
- Ministério da Saúde (ST)
Publication Details
- Journal
- Diagnostic Microbiology and Infectious Disease
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1016/j.diagmicrobio.2025.116929
- Primary Topic
- Leprosy Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico