Detection of early Parkinson’s disease using 5-hydroxymethylcytosine episignatures in blood DNA
Our study provides the first evidence that blood-based hydroxymethylome profiles are promising biomarkers for the early diagnosis of PD.
Authors
- Ya-Dan Song
- Jian‐Hong Zhu (ORCID: https://orcid.org/0000-0001-9412-8264)
- Xiao‐Yong Fan (ORCID: https://orcid.org/0000-0001-6654-3559)
- Dao‐Lu Zhang (ORCID: https://orcid.org/0000-0002-3490-2585)
- Lei Cui (ORCID: https://orcid.org/0000-0003-2394-7451)
- Beilei Hu (ORCID: https://orcid.org/0000-0001-5429-3337)
- Hongmei Wu (ORCID: https://orcid.org/0000-0002-1930-1183)
- Xiong Zhang (ORCID: https://orcid.org/0000-0002-9944-9638)
- Jianyong Wang (ORCID: https://orcid.org/0000-0003-4695-4806)
- Qing Guo (ORCID: https://orcid.org/0009-0008-3193-550X)
- Jie Deng (ORCID: https://orcid.org/0000-0002-3691-1717)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Age and Ageing
- Published
- 2025-05-31
- DOI
- https://doi.org/10.1093/ageing/afaf147
- Citations
- 2
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78