[Effects of Yishen Yangsui formula() on pyroptosis in the spinal cord tissue in rats with degenerative cervical myelopathy].
YSYSF can improve the motor function of rats with degenerative cervical spinal cord disease, alleviate the pathological changes, and promote the recovery of spinal cord neurological function. The specific mechanism may be related to the inhibition of the activation of inflammatory vesicles NLRP3 and PYCARD, the reduction of the release of inflammatory factors IL-1β and IL-18, the reduction of the expression of caspase-1 and GSDMD, the reduction of cellular death, and the inhibition of inflammatory response.
Authors
- Dan Zhang (ORCID: https://orcid.org/0000-0001-5140-3588)
- Minshan Feng (ORCID: https://orcid.org/0000-0003-1130-3085)
- Liguo Zhu (ORCID: https://orcid.org/0000-0003-2593-7978)
- Xiaokuan Qin (ORCID: https://orcid.org/0000-0002-6993-1247)
- Bowen Yang (ORCID: https://orcid.org/0000-0002-3557-6814)
- Bo Xu (ORCID: https://orcid.org/0000-0002-3666-8905)
- He Yin (ORCID: https://orcid.org/0000-0001-8194-3542)
- Dian Zhang (ORCID: https://orcid.org/0000-0002-0696-2855)
- Xin Chen (ORCID: https://orcid.org/0000-0002-5579-0447)
- Guo-Liang Ma
Institutions
- Wangjing Hospital of China Academy of Chinese Medical Sciences (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-05-25
- DOI
- https://doi.org/10.12200/j.issn.1003-0034.20240880
- Primary Topic
- Cervical and Thoracic Myelopathy
- Type
- article