[Genetic and clinical characteristics of children with <i>RAS</i>-mutated juvenile myelomonocytic leukemia].
Children with <i>NRAS</i> compound mutations have a later onset age compared to those with isolated <i>NRAS</i> mutations. At initial diagnosis, children with <i>NRAS</i> compound mutations have poorer peripheral platelet and fetal hemoglobin levels than those with isolated <i>NRAS</i> mutations. Liver size at initial diagnosis is related to the prognosis of JMML children with <i>RAS</i> mutations. HSCT can improve the prognosis of JMML children with <i>RAS</i> mutations.
Authors
- Xing-Chen Wang (ORCID: https://orcid.org/0000-0001-5557-4966)
- Yingchi Zhang (ORCID: https://orcid.org/0000-0003-1429-0152)
- Xiaofan Zhu (ORCID: https://orcid.org/0000-0002-2572-6495)
- Chengming Liu (ORCID: https://orcid.org/0000-0002-5818-4848)
- Ye Guo (ORCID: https://orcid.org/0000-0002-1813-9815)
- Jingliao Zhang (ORCID: https://orcid.org/0000-0003-2962-9884)
- Tianyuan Hu (ORCID: https://orcid.org/0000-0002-8145-5802)
- Li Zhang (ORCID: https://orcid.org/0000-0002-3919-3247)
- Fang Liu (ORCID: https://orcid.org/0000-0002-9004-1599)
- Xiaojuan Chen (ORCID: https://orcid.org/0000-0002-6971-3442)
- Yunlong Chen (ORCID: https://orcid.org/0000-0002-1852-9688)
- Yumei Chen (ORCID: https://orcid.org/0000-0002-0241-7577)
- Yao Zou (ORCID: https://orcid.org/0000-0003-1418-7331)
- Wenyu Yang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Institute of Hematology & Blood Diseases Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-05-15
- DOI
- https://doi.org/10.7499/j.issn.1008-8830.2411018
- Primary Topic
- Child and Adolescent Health
- Type
- article