Pain Management in Mild Traumatic Brain Injury: Central Sensitization as a Multispecialty Challenge.

We showed that high levels of central sensitization were universally present in the cohort studied and should be considered the primary therapeutic target in managing chronic post-mTBI pain. Therefore, chronic pain in this population is likely driven by central nervous system pathology that contributes to both the pain experience and other post-concussive symptomatology. A significant clinical implication of our study is that patients displaying high levels of central sensitization often report severe pain in discrete body parts, leading clinicians to mistakenly focus on treating the issue with antinociceptive therapies or interventional procedures that are frequently ineffective.