The Efficacy and Safety of Applying the Combination of Pulsed Radiofrequency and Platelet-Rich Plasma to the Gasserian Ganglion for the Treatment of Idiopathic Trigeminal Neuralgia: A Protocol for a Multi-Center, Prospective, Open-Label, Propensity S

To our knowledge, this trial will be the first multi-centric, prospective, observational study that has a relatively large sample size and compares the efficacy and safety of applied PRF to that of combined PRF and PRP for patients who have not responded to pharmacologic treatments for idiopathic TN. If the combination PRF-and-PRP treatment is proven effective, it will be an important, safe, minimally destructive alternative treatment modality for idiopathic TN that persists after ineffective conservative treatment.