Trends in lung cancer incidence and non-small cell lung cancer diagnosis (2008-2022): A global and vietnamese perspective

Objectives: 1) Describe trends in lung cancer (LC) incidence and 2) Describe trends in Non-Small Cell Lung Cancer (NSCLC) diagnosis in global and in Vietnam during 2008-2022. Methods: Extensive medical databases, including Medline/PubMed and GLOBOCAN as well as domestic medical journals, research papers, dissertations, and conference re-ports globally and in Vietnam up to September 2023, were utilized. Zotero 6.0 was em-ployed for document management and citation. The articles and scientific reports on the trends in LC incidence and in NSCLC diagnosis in global and in Vietnam during 2008-2022. Results: 28 studies and reports in global and in Vietnam were selected for the study. Among them, there were 15 documents about the trends of LC incidence, and 13 docu-ments about the trend NSCLC diagnosis. The incidence of new LC tends to increase in global and in Vietnam, there are differences between men and women and regions in the world, men have a higher incidence rate than women, regions with poor economic con-ditions. In developed economies, the incidence rate is higher than in areas with less de-veloped economies. The mortality rate due to LC is always high due to late diagnosis in the late stages of the disease. In Vietnam, the number of new cases has increased, but the rate of new cases of LC has gradually decreased after 2012. In global as well as in Vietnam, the rate of new cases of LC in men tends to decrease, while in women it tends to increase. The results of histopathological and immunohistochemical staining tech-niques are considered the gold standard for NSCLC diagnosis in global and in Vietnam; Especially, liquid biopsy has been applied in the diagnosis and support for treatment of NSCLC patients. Conclusion: Vietnam is in the trend of increasing the LC incidence in global with men higher than women. The growth rate of new cases in men tends to decrease but increas-es in women. The results of histopathological and immunohistochemical staining tech-niques are considered the gold standard for NSCLC diagnosis; Especially, liquid biopsy promises to be highly effective in early diagnosis and support for NSCLC treatment thereby bringing hope for life to patients and their family. Key words: Lung cancer (LC); Non-Small Cell Lung Cancer (NSCLC); Trend; Diagno-sis; Global; Vietnam.