Formulation & Evaluation of Butterfly Pea Extract Loaded Nasal Spray for Treating Alzheimer’s Disease

Alzheimer’s disease (AD) represents a progressive degenerative brain condition that produces memory deterioration together with cognitive impairment and behavioral problems. Pharmacological therapy for AD remains limited because available drugs show low availability in the body while failing to penetrate the blood-brain barrier efficiently. This research develops and assesses a nasal spray formulation based on Butterfly Pea Flower (Clitoria ternatea) because it shows neuroprotective along with antioxidant effects combined with cognitive enhancement capabilities. The nasal pathway enables drug administration through neural pathways to the brain without passing through the BBB which results in improved treatment response. The formulation underwent in vitro evaluations that evaluated its performance through measurement of pH and viscosity and drug content determination and drug release tests. The developed formulation presented desirable chemical properties along with reliable drug release patterns and good permeation of nasal mucosal barriers. The discovery shows that a nasal spray made from Butterfly Pea Flower has potential as an alternative herbal therapy to treat Alzheimer's disease through improved cognition and disease speed control. Additional clinical evaluations and in vivo studies should be performed to verify these findings and prove both performance and safety in human medical trials regarding the formulation.