The Buschke-Lowenstein Tumour and Review of Literature

Buschke-Löwenstein tumour (TBL), or giant acuminate condyloma, is a sexually transmitted infection caused primarily by human papillomavirus (HPV) types 6 and 11. It develops after acuminate condylomas and is distinguished by marked proliferation, deep growth, and potential for recurrence despite a benign histology. Its location is often genital, with frequent involvement of the penis in men and vulva in women, as well as anorectal cases. We presented three cases of BBT with genital, perineal and intergluteal localization, whose surgical sequelae were simple, without recurrence observed after one year of follow-up. The disease progresses slowly and can lead to serious complications such as infections, fistulas or necrosis. The diagnosis is based on an anatomopathological examination, which reveals epithelial hyperplasia without invasion of the basal membrane, sometimes associated with koilocytes. The main treatment is surgical, often wide and sometimes mutilating to avoid relapses. Local treatments (laser, cryotherapy) and medical approaches such as chemotherapy or immunotherapy are sometimes used but their effectiveness remains limited. Radiotherapy and chemotherapy are reserved for inoperable or recurrent cases. Multidisciplinary management and long-term monitoring are essential to prevent recurrence.