Associations among IL-6 Signaling Molecules in Treg Populations in Patients with Relapsing-Remitting Multiple Sclerosis
Our findings underscore the complex interplay between IL-6 signaling and Tregs as well as age-related immune regulation. The observed alterations in the expression of receptors and in signaling activity may contribute to the dysregulation of CD8<sup>+</sup>CD122<sup>+</sup> Treg function activated via the classic IL-6 pathway and suggests IL-6 trans-signaling in CD25-positive Tregs. RRMS may interfere with normal immune aging patterns, possibly by promoting a sustained inflammatory state that overrides the senescence of Tregs.
Authors
- Rafał Rola (ORCID: https://orcid.org/0000-0002-9388-5578)
- Marta Maruszewska‐Cheruiyot (ORCID: https://orcid.org/0000-0002-6595-6228)
- Magdalena Kierasińska (ORCID: https://orcid.org/0000-0001-9274-248X)
- Katarzyna Donskow‐Łysoniewska (ORCID: https://orcid.org/0000-0003-4924-800X)
- Ludmiła Szewczak (ORCID: https://orcid.org/0000-0002-4104-3088)
- A Karlińska
- M.J. Stear (ORCID: https://orcid.org/0000-0001-5054-1348)
- Maja Machcińska (ORCID: https://orcid.org/0000-0001-5458-0096)
Institutions
- La Trobe University (AU)
- Medical University of Warsaw (PL)
- Wojskowy Instytut Medycyny Lotniczej (PL)
- Uczelnia Łazarskiego (PL)
- Wojskowy Instytut Higieny i Epidemiologii (PL)
- AgriBio (AU)
Publication Details
- Journal
- Journal of Integrative Neuroscience
- Published
- 2025-05-26
- DOI
- https://doi.org/10.31083/jin36207
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Fundacja na rzecz Nauki Polskiej
- European Regional Development Fund