A Rat Model of Hyperoxia-Induced White Matter Injury

Hyperoxia causes WMI in neonatal rat brains. Exposure of neonatal rats to 80% oxygen for 5 d induces a reliable animal model of hyperoxia-induced WMI. Aberrant differentiation and apoptosis of oligodendrocytes might be the reason for hyperoxia-induced WMI.

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Publication Details

Journal
Journal of Integrative Neuroscience
Published
2025-05-23
DOI
https://doi.org/10.31083/jin36216
Primary Topic
Neonatal and fetal brain pathology
Type
article
Field-Weighted Citation Impact
0.00

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article

A Rat Model of Hyperoxia-Induced White Matter Injury

Yue Song, Hua Wang, Ting Zhang
Journal of Integrative Neuroscience
Neonatal and fetal brain pathology
article

A Rat Model of Hyperoxia-Induced White Matter Injury

Yue Song, Hua Wang, Ting Zhang
article en

Abstract

Hyperoxia causes WMI in neonatal rat brains. Exposure of neonatal rats to 80% oxygen for 5 d induces a reliable animal model of hyperoxia-induced WMI. Aberrant differentiation and apoptosis of oligodendrocytes might be the reason for hyperoxia-induced WMI.

Journal of Integrative NeuroscienceVol. 24(5)
Sichuan University (CN), West China Second University Hospital of Sichuan University (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 82%
Neonatal and fetal brain pathology
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