METTL3-Driven m6A Modification of Cpt1a Gene in High Fat Diet Related Liver Cancer Tumor Macrophages Facilitates Type II Macrophage Differentiation
Our research identifies that a high-fat diet elevates METTL3-driven m6A modification of carnitine palmitoyltransferase 1A (CPT1A) in tumor macrophages, fostering type II macrophage differentiation, and exacerbating liver cancer growth and immune evasion.
Authors
- Wenting Wang
- Xueqi Li (ORCID: https://orcid.org/0000-0002-9329-3257)
- Limei Zhu (ORCID: https://orcid.org/0009-0008-7876-1324)
Institutions
- The First People’s Hospital of Lianyungang (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-05-26
- DOI
- https://doi.org/10.31083/fbl36971
- Citations
- 5
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.03