Empiric Antibiotic Therapy in Suspected Sepsis: Impact of Gentamicin-Based Regimens on Incident Renal Failure and Mortality
In patients with suspected sepsis, empirical treatment with narrow-spectrum β-lactam/gentamicin was not associated with an increased risk of AKI or death. If local antimicrobial resistance patterns permit, narrow-spectrum β-lactam/gentamicin may reduce broad-spectrum β-lactam usage, addressing a key element of antibiotic stewardship.
Authors
- Jan‐Erik Berdal (ORCID: https://orcid.org/0000-0002-7299-6199)
- Olav Dalgård (ORCID: https://orcid.org/0000-0003-4470-3181)
- Magnus Nakrem Lyngbakken (ORCID: https://orcid.org/0000-0002-5994-9304)
- Magrit Jarlsdatter Hovind (ORCID: https://orcid.org/0009-0000-0654-6897)
Institutions
- University of Oslo (NO)
- Akershus University Hospital (NO)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-05-31
- DOI
- https://doi.org/10.1093/ofid/ofaf319
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00