Trimethylamine N-oxide Supplementation Enhances the Quality of Oocytes in Mice of Polycystic Ovary Syndrome
Our findings indicate that the reduction in TMAO levels induced by PCOS may be a key factor influencing reproductive outcomes. TMAO supplementation <i>in vivo</i> can effectively enhance mitochondrial function and oocyte quality in PCOS, holding significant clinical importance for improving assisted reproductive outcomes in patients with PCOS.
Authors
- Xiru Liu (ORCID: https://orcid.org/0000-0002-6134-6748)
- Jiying Hou (ORCID: https://orcid.org/0000-0002-3785-2181)
- Yin Tian (ORCID: https://orcid.org/0009-0000-1965-7406)
- Jingyu Li (ORCID: https://orcid.org/0000-0003-0136-532X)
- Zixin Xu
- Chong Li (ORCID: https://orcid.org/0009-0009-1230-2528)
- Ling Zhu (ORCID: https://orcid.org/0009-0009-1495-2110)
- Xuemei Liu (ORCID: https://orcid.org/0000-0003-3474-0990)
- Jiayu Huang (ORCID: https://orcid.org/0000-0002-7517-4369)
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical and Pharmaceutical College (CN)
- The University of Tokyo (JP)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-05-22
- DOI
- https://doi.org/10.31083/fbl38078
- Citations
- 1
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China