TNIK Regulates Cytoskeletal Organization to Promote Focal Adhesion Turnover and Mitosis in Lung Adenocarcinoma
Our findings suggest that TNIK regulates focal adhesion turnover and mitosis to promote tumor malignancy via the RHO/ROCK2/LIMK1 pathway. The combination of TNIK targeting with chemotherapeutic drugs could be an effective strategy to overcome resistance in LUAD.
Authors
- Chun-dong Zhang
- Manrong Song
- Xing Hu (ORCID: https://orcid.org/0009-0000-9096-541X)
- Lian Zhang (ORCID: https://orcid.org/0009-0003-5317-0484)
- Tao Zhang (ORCID: https://orcid.org/0000-0002-5607-4610)
- Lu Zhang (ORCID: https://orcid.org/0009-0009-5628-9732)
- Qian Zhang (ORCID: https://orcid.org/0000-0002-2858-4840)
- Li Yao (ORCID: https://orcid.org/0000-0001-6356-7926)
- Xuehua Sun
- Yingxiong Wang
Institutions
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-05-22
- DOI
- https://doi.org/10.31083/fbl38875
- Primary Topic
- Cellular Mechanics and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chongqing Postdoctoral Science Foundation
- National Natural Science Foundation of China
- Chongqing Medical University
- Natural Science Foundation of Chongqing
- Centre Scientifique et Technique du Bâtiment