Design and Comparative Analysis of Biosensing Devices with Different Dielectric Materials for Blood Cancer Detection

The healthcare industry is constantly changing due to technological breakthroughs that spur new methods of diagnosing and treating illnesses. In this study, we suggested a novel structure for a label-free biosensor that senses both charged and neutral bioanalytes: the dielectric modulated dual-dielectric Ion-Sensitive Field Effect Transistor. Compared to Nanosheet FET (NSFET), the ISFET device shows better bio-sensing ability. Al2O3 oxide is substantially more sensitive than other oxides when pH 7.4 is considered. The resulting 2D-ISFET has the potential to be a rapid blood cancer screening tool due to its exceptional blood electrolyte sensitivity. The findings demonstrate that the ISFET has reduced Subthreshold Swing (SS), Increased ON-current (ION) and switching ratio, and drain-induced barrier lowering. The recommended apparatus and the pH sensor's sensitivity may identify blood cancer indicators as high as 30 fg/mL. A significant advancement in technology-driven healthcare is using ISFET sensors for DNA-based blood cancer detection. This creates new opportunities to enhance patient outcomes and cancer diagnosis. Its excellent sensitivity, selectivity, low detection limit, thermal stability, biocompatibility, and affordability make it a promising material for a wide range of flexible sensing applications in the future. In our work, we have mainly focused on blood cancer detection. The proposed biosensors signify a significant advancement in technology-driven healthcare, offering new possibilities for enhancing cancer diagnostics and patient outcomes.