HMGB1 Mediates Microglia-Astrocyte/Neuron Crosstalk and Pyroptosis by the TLR4/NF-κB Pathway in Multiple Sclerosis
HMGB1 has the potential to act as a promoter of MS through the activation of TLR4/NF-κB signaling pathway and the induction of pyroptosis in microglial and other cells. Consequently, the modulation of HMGB1 may represent a novel therapeutic strategy for the management of MS.
Authors
- Zhuofeng Mao (ORCID: https://orcid.org/0009-0003-1606-6311)
- Weiping Wang (ORCID: https://orcid.org/0000-0002-9337-8496)
- Feng Yang (ORCID: https://orcid.org/0009-0006-4079-2112)
- Liang Wang (ORCID: https://orcid.org/0009-0008-4662-2370)
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-05-23
- DOI
- https://doi.org/10.31083/fbl37838
- Citations
- 5
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 6.59
Funders
- Natural Science Foundation of Hebei Province