HOTAIR Knockdown Increases the Sensitivity of Hepatocellular Carcinoma Cells to Sorafenib by Disrupting miR-145-5p/HK2 Axis-Mediated Mitochondrial Function and Glycolysis
<i>HOTAIR</i> knockdown increased the sensitivity of HCC cells to sorafenib by disrupting the miR-145-5p/HK2 axis-mediated mitochondrial function and glycolysis, suggesting new strategies for HCC treatment.
Authors
- Jin Yu (ORCID: https://orcid.org/0000-0001-8224-1374)
- Bingrong Wang (ORCID: https://orcid.org/0000-0002-9245-4872)
- Meiyu Cheng
- Na Li (ORCID: https://orcid.org/0000-0001-5366-2233)
- Wenda Zhang (ORCID: https://orcid.org/0000-0002-7505-253X)
- Lina Duan (ORCID: https://orcid.org/0000-0001-5970-9899)
Institutions
- Yanbian University (CN)
- Jilin University (CN)
- Jilin Medical University (CN)
- Hebei University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-05-23
- DOI
- https://doi.org/10.31083/fbl37368
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Jilin University
- Hebei University
- Fundamental Research Funds for the Central Universities