Inhibition of Activated Coagulation Factor XII by the Phosphodiesterase-4 Inhibitor Roflumilast: In Vitro and In Silico Studies
Overall, roflumilast could be used as a lead compound for developing a novel multifunctional therapeutic drug used for the prevention of HAE or thrombotic disorders.
Authors
- Hassan Madkhali (ORCID: https://orcid.org/0000-0002-0267-4194)
- Mubarak A. Alamri (ORCID: https://orcid.org/0000-0003-0678-593X)
- Mohd Nazam Ansari (ORCID: https://orcid.org/0000-0001-8580-3002)
Institutions
- Prince Sattam Bin Abdulaziz University (SA)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-05-21
- DOI
- https://doi.org/10.31083/fbl38395
- Citations
- 1
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 1.63