134 Evaluation of Antiseizure Medication Impact on Efficacy of Direct Oral Anticoagulants

Introduction: Concomitant use of direct oral anticoagulants (DOAC) and antiseizure medications (ASM) is common. Historically, levetiracetam (LEV) and valproic acid (VPA) have been favored in patients on DOAC therapy due to limited drug-drug interactions; however, a recent large claims-based study found concurrent use of DOAC and LEV or VPA was associated with increased risk of thrombotic events. The goal of our study was to evaluate the incidence of thrombotic events with concurrent DOAC and LEV and/or VPA therapy.