160 Evaluation of Heparin Nomogram Performance in Under- and Overweight Patients

Introduction: The 2012 Antithrombotic Therapy and Prevention of Thrombosis guidelines recommend weight-based dosing for unfractionated heparin (UFH) as standard of care for achieving therapeutic aPTT as shown by Raschke et al. While there are currently no published studies evaluating therapeutic UFH dosing in underweight patients, retrospective studies have demonstrated that obese patients require lower doses due to differences in distribution. Prior data from The Johns Hopkins Hospital (JHH) corroborated this finding in an obese cohort which led to implementation of reduced weight-based dosing using actual body weight for obese patients.