192 Evaluating the Effectiveness and Tolerability of UFH vs. LMWH for VTE Prevention in Underweight Patients: A Retrospective Cohort Study

Introduction: Venous thromboembolism (VTE) poses a major risk in hospitalized patients, with deep vein thrombosis (DVT) and pulmonary embolism (PE) affecting nearly 900,000 Americans annually. Thromboprophylaxis reduces VTE incidence by up to 65%, but optimal dosing remains unclear for underweight patients, who face higher bleeding risks. Current guidelines lack clarity on dosing adjustments for patients ≤50 kg or BMI ≤18.5 kg/m2. This study aims to evaluate VTE prophylaxis patterns and assess VTE and bleeding incidence in underweight patients, addressing a critical gap in evidence for this high-risk population.