137 Real-World Implementation of Latex Immunoturbidimetric Platelet Factor 4 Assay for Heparin-Induced Thrombocytopenia Diagnosis at a Large Academic Medical Center
Introduction: Heparin-induced thrombocytopenia (HIT) is a rare complication of heparin use, characterized by increased thrombotic risk. Diagnosis includes calculating the pre-test probability of HIT using the 4T score, running a platelet factor 4 (PF4) assay to screen for anti-heparin/PF4 antibodies, and confirming results with a serotonin release assay (SRA) to assess for platelet activation. Our institution switched from an enzyme-linked immunosorbent PF4 assay batched once daily to a latex immunoturbidimetric assay (LIA) run on-demand.
Authors
- Elisabeth M. Battinelli (ORCID: https://orcid.org/0000-0003-1916-047X)
- Katelyn W. Sylvester (ORCID: https://orcid.org/0000-0001-9208-2354)
- Gustavo Sánchez Torres
- Dareen M. Kanaan (ORCID: https://orcid.org/0000-0003-4942-6689)
- Jean M. Connors (ORCID: https://orcid.org/0000-0001-6445-582X)
- A. Zhang (ORCID: https://orcid.org/0000-0002-1463-2549)
- Daniel C. Dees
Institutions
- Brigham and Women's Hospital (US)
- Brigham and Women's Faulkner Hospital (US)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.rpth.2025.102785
- Primary Topic
- Heparin-Induced Thrombocytopenia and Thrombosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00