168 Fat-Specific S6 Kinase Gene Inhibition: A Novel Strategy to Improve Metabolic Health and Anticoagulation Outcomes in Diabetes-Associated Thrombosis

Introduction: Type 2 diabetes (T2D) is associated with increased thrombosis risk due to chronic inflammation and metabolic dysregulation. Current therapies targeting systemic pathways often have significant side effects, highlighting the need for tissue-specific interventions. This study investigates whether selective inhibition of the S6 kinase (S6K) gene in adipose tissue can improve systemic health and hemolymph coagulation in Drosophila melanogaster.