103 Assessing Anticoagulation Status of a Patient with APS Using Chromogenic Factor X Testing

Introduction: Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by thrombosis and/or pregnancy morbidity in association with persistently positive antiphospholipid antibodies (aPL). The standard treatment for thrombotic APS is life-long warfarin therapy, which requires regular monitoring via the International Normalized Ratio (INR). The presence of Lupus Anticoagulant (LA) can affect the phospholipid component of the INR test, making it challenging to monitor warfarin in APS patients.