104 To Prescribe or Deprescribe: Antiplatelet Discontinuation versus Proton Pump Inhibitor (PPI) Addition in Veterans with Combined Antithrombotic Therapy

Introduction: Combined antithrombotic therapy (CAT) with an anticoagulant and an antiplatelet (APT) is often indicated for patients with multiple cardiovascular disorders, however this combination carries an increased risk of bleeding, especially gastrointestinal bleeding (GIB). PPIs have emerged as an option for reducing the risk of GIB. The purpose of this study is to review medical records of Veterans on CAT and assess appropriateness of both anticoagulant and/or APT therapy for possible de-escalation of therapy.