Performance of volume and diameter thresholds in malignancy prediction of solid nodules in lung cancer screening
Solid nodules <100 mm<sup>3</sup> or <6 mm diameter are not associated with increased risk of lung cancer compared with participants with no nodules at baseline LDCT. Volumetric rule-out thresholds achieve equivalent NPV to long-axis diameter thresholds while encompassing significantly more participants, reducing the number of interval scans required.
Authors
- Amyn Bhamani (ORCID: https://orcid.org/0000-0002-8575-6119)
- Neal Navani (ORCID: https://orcid.org/0000-0002-6412-7516)
- John P. McCabe (ORCID: https://orcid.org/0000-0001-5201-9174)
- Allan Hackshaw (ORCID: https://orcid.org/0000-0002-5570-5070)
- Priyam Verghese (ORCID: https://orcid.org/0000-0002-1319-3986)
- Carolyn Horst (ORCID: https://orcid.org/0000-0003-2427-6610)
- Anand Devaraj
- Sophie Tisi
- Jennifer Dickson (ORCID: https://orcid.org/0000-0002-9333-8320)
- Kylie Gyertson
- Chuen R Khaw
- Laura Farrelly (ORCID: https://orcid.org/0000-0002-0039-6709)
- Shrinkhala Dawadi (ORCID: https://orcid.org/0000-0002-4085-9181)
- Sam M. Janes (ORCID: https://orcid.org/0000-0002-6634-5939)
- Andrew Creamer (ORCID: https://orcid.org/0000-0002-9314-1210)
- Helen Hall (ORCID: https://orcid.org/0000-0001-7305-8367)
- Arjun Nair (ORCID: https://orcid.org/0000-0001-9270-3771)
- Ruth Prendecki
- Anne-Marie Hacker
- Jonathan Teague
- Tanita Limani
Institutions
- University College London Hospitals NHS Foundation Trust (GB)
- Cancer Research UK (GB)
- Royal Brompton Hospital (GB)
- The London College (GB)
- University College London (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Thorax
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1136/thorax-2024-222086
- Citations
- 3
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- Wellcome Trust