Biological characteristics of spontaneous ovarian cancer in <i>Microtus</i><i>fortis</i>.
Spontaneous ovarian cancer in <i>M. fortis</i> is serous ovarian cancer. Compared to healthy <i>M. fortis</i>, significant differences were observed in ovarian tissue morphology, biochemical indicators, ovarian cancer-related gene expression, and protein expression, which show similarity to the biological characteristics of human serous ovarian cancer. This suggests that <i>M. fortis</i> could be an ideal animal model for studying human serous ovarian cancer.
Authors
- Wenling Zhi
- Yixin Wen (ORCID: https://orcid.org/0000-0003-1618-1208)
- Tianqiong He
- Xin Gao (ORCID: https://orcid.org/0000-0001-8736-1172)
- Qian Liu (ORCID: https://orcid.org/0000-0002-8078-1075)
- Zhijun Zhou (ORCID: https://orcid.org/0000-0002-2407-2071)
- Zikang Zhou
- Junkang Zhou
- Yushan Qi
- Lingxuan Ouyang
Institutions
- Central South University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-28
- DOI
- https://doi.org/10.11817/j.issn.1672-7347.2025.240440
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00