A genome-wide RNA interference screening reveals protectiveness of SNX5 knockdown in a Parkinson’s disease cell model
In summary, our data suggest that SNX5 plays an important role in the trafficking and toxicity of αSyn. Therefore, SNX5 appears to be a target of therapeutic intervention for synucleinopathies.
Authors
- Oscar Wing Ho Chua (ORCID: https://orcid.org/0000-0002-5572-7907)
- Franziska Hopfner (ORCID: https://orcid.org/0000-0001-6524-0281)
- Marc Bickle (ORCID: https://orcid.org/0000-0002-8918-1869)
- Claudia Moebius
- Matthias Höllerhage (ORCID: https://orcid.org/0000-0002-5333-0121)
- Franziska Richter (ORCID: https://orcid.org/0000-0003-0803-4398)
- Linghan Duan (ORCID: https://orcid.org/0000-0001-6368-484X)
- Günter U. Höglinger (ORCID: https://orcid.org/0000-0001-7587-6187)
- Christian Wahl‐Schott (ORCID: https://orcid.org/0000-0002-7514-2367)
- Svenja Bothe
- Rebecca Kotzur
- Kristina Lau
- Kristina Losse
Institutions
- University of Veterinary Medicine Hannover, Foundation (DE)
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- Medizinische Hochschule Hannover (DE)
- Munich Cluster for Systems Neurology (DE)
- Max Planck Institute of Molecular Cell Biology and Genetics (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Translational Neurodegeneration
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s40035-025-00486-5
- Citations
- 2
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- ParkinsonFonds Deutschland
- Deutsche Forschungsgemeinschaft
- Volkswagen Foundation
- Bundesministerium für Bildung und Forschung