Effects of a Low Versus Moderate–High Intense Exercise Program on Innate Immune Recovery, Fitness, and Quality of Life During Pediatric Allo‐HSCT—The ANIMAL Exploratory Randomized Controlled Trial
This pilot study implied a trend toward improved immune recovery with moderate to vigorous exercise. Importantly, both programs were safe and feasible. The higher intensity intervention showed significant benefits on leg strength and specific innate immune cell populations, but these findings must be considered preliminary in the context of the exploratory nature of the study.
Authors
- Ronja Beller (ORCID: https://orcid.org/0000-0002-2779-0562)
- Helmut Hanenberg (ORCID: https://orcid.org/0000-0003-0451-2735)
- Constanza Viña
- Gabriele Gauß
- Miriam Götte (ORCID: https://orcid.org/0000-0003-0841-8738)
- Dirk Reinhardt (ORCID: https://orcid.org/0000-0002-7027-4483)
- Sabrina B. Bennstein (ORCID: https://orcid.org/0000-0003-0477-2748)
- Markus Uhrberg (ORCID: https://orcid.org/0000-0001-9553-1987)
Institutions
- University of Calgary (CA)
- Düsseldorf University Hospital (DE)
- Alberta Cancer Foundation (CA)
- Essen University Hospital (DE)
- Gesellschaft für Nuklear Service (Germany) (DE)
- West German Heart and Vascular Center Essen (DE)
- Heinrich Heine University Düsseldorf (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1002/pbc.31826
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Universität Duisburg-Essen