KAT2A knockdown induces microglia M2 polarization by succinylation of PRDX3 after traumatic brain injury
Silencing of KAT2A promotes microglia polarization from M1 to M2 phenotype by inhibiting the succinylation of PRDX3 at K84 site, suggesting a potential strategy for reducing neuroinflammation after TBI.
Authors
- Jingjing Mao (ORCID: https://orcid.org/0000-0003-2168-5961)
- Kailiang Tao
- Peng An (ORCID: https://orcid.org/0009-0007-4915-347X)
- Zhenfei Yu (ORCID: https://orcid.org/0000-0002-1225-5444)
- Jun Dong
Institutions
- Zhejiang Chinese Medical University (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- CM Hospital (KR)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Neurological Research
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1080/01616412.2025.2515189
- Citations
- 1
- Primary Topic
- Nitric Oxide and Endothelin Effects
- Type
- article
- Field-Weighted Citation Impact
- 1.16