Herbal Patch for Anti-Inflammatory Activity of Plant Calotropis Gigantea

The plant of Calotropis gigantea are traditionally used to cure cancer, intermittent fever, paralyzed part of body, painful joints, swelling, heals wounds.Also used as an antispasmodic, antiasthmatic, externally used for piles, boils, ulcers, scabies, eczema, leprosy.It is having promising anti-inflammatory activity.However, its anti -inflammatory activity is not scientifically documented.The herbal patch of Calotropis gigantea was prepared by solvent casting method, in this method the herbal extract of Calotropis gigantea and excipient i.e.HPMC, MC, Ethanol, Distilled water, Glycerin, chloroform, PVP.Hence, the present study was under taken to evaluate anti-inflammatory activity of Calotropis gigantean leaves extract using in -vitro method.The extract was screened for in vitro anti -inflammatory activity by using inhibition of albumin denaturation technique which was studied.Which indicates that Calotropis gigantea leaves extract possess significant antiinflammatory activity.Finally the three formulation was prepared i.e.Herbal patch-I(HP-I), Herbal patch-II (HP-II), Herbal patch-III, And all the formulation was evaluated by various parameters like; physical evaluation, weight of the patch, thickness of patch, folding endurance, moisture uptake, moisture content and percentage flatness.We start by summarizing the main findings of our study, emphasizing the effectiveness of the herbal patch in reducing inflammation.In this study we prepare three formulations, that can be herbal patch-I (HP-I), herbal patch-II (HP-II) and herbal patch-III (HP-III).According to the standard parameters of transdermal patch we observed that the HB-III formulation was better than HB-I and HB-II because it may be stable follows all the parameters of standard procedure.