Formulation and evaluation of sustain release metformin tablets by wet granulation method for Enhanced Patient Compliance

By using the wet granulation process, sustained release tablets of metformin were successfully made using a variety of polymers, including xanthan gum and Karaya gum.There were no compatibility issues with the excipients utilized in the trial, according to preformulation tests for drug excipient compatibility.In order to provide a controlled release of the medication, guarantee long-lasting therapeutic benefits, and minimize the frequency of dose, the goal of this study was to develop and assess metformin hydrochloride sustained-release tablets.Using hydroxypropyl methylcellulose (HPMC) as a rate-controlling polymer and other excipients such microcrystalline cellulose (MCC), magnesium stearate, and povidone, sustained-release formulations of metformin were created.Direct compression was used to create the tablets, which were then examined for a number of physical and chemical characteristics.For MET to increase patient compliance and extend its duration of action, SR products are required.Formulation scientists have faced difficulties in developing oral sustained release systems since they are unable to confine and localize the system at certain gastrointestinal tract locations.Tests for weight fluctuation, hardness, friability, thickness, dissolution, content uniformity, and assay were all part of the post-compression evaluation.The toughness of the tablets was ensured by their uniform weight fluctuation (5% of the average weight), acceptable hardness (8-10 kg), and minimum friability (0.4% weight loss).The thickness (4.5 mm 5%) was constant.With 12.5% of the medication released in the first hour and 92% after 8 hours, the dissolving trials showed a regulated release profile, suggesting that the tablets offer a gradual release of the medication.