Formulation and Evaluation of Transdermal drug delivery system of an anti-inflammatory drug using essential oil as penetration enhancer.

This study focuses on formulation and evaluation of transdermal patches of Lornoxicam using various polymers to study drug release profiles and enhance transdermal drug delivery.Lornoxicam a non-steroidal anti-inflammatory drug (NSAID) is commonly associated with oral side effects such as non-compliance due to frequent dosing, gastro-intestinal irritation and ulcerogenicity.To address these limitations transdermal delivery offers a promising alternative by providing controlled drug release and improving patient compliance.The transdermal patches were prepared using the solvent casting method with HPMC K15M and Eudragit L 100 as the polymers and lavender oil as penetration enhancer.Nine formulations (F1-F9) were developed with different polymer ratios and evaluated for various physicochemical properties including thickness, weight, folding endurance, tensile strength, moisture content and drug content.FTIR analysis confirmed the chemical compatibility between the drug and polymers while Scanning Electron Microscopy (SEM) demonstrated uniform surface morphology In-vitro diffusion studies showed that formulation F8 comprising HPMC K15M and Eudragit L 100 in a 4:1 ratio and with 22 % of penetration enhancer provided the most sustained drug release 61.18 % over 8 hours following a non-fickian diffusion mechanism.The selected formulation F8 was subjected to stability testing for 8 weeks, the results confirmed the stability of prepared patches.In conclusion, F8 was identified as the most promising formulation due to its superior drug release profile, mechanical properties, and stability suggesting its potential as an effective transdermal delivery system for Lornoxicam.