Formulation and Evaluation of Oral Controlled release Tablet of Losartan

Studies have been carried out to develop oral controlled release matrix tablet formulations of losartan potassium employing polymeric materials such ethylcellulose, sodium alginate, xanthan gum, guar gum, karaya gum, polyox WSR 301, and polyox WSR 303.Due to their claimed matrix forming properties, they are chosen as matrix forming polymers for controlled release.The drug content, hardness, friability, and weight consistency of the produced matrix tablets were assessed.To look for any interactions between the medicine and the excipients used in the formulation of matrix tablets, these investigations were conducted on the tablets prior to their being subjected to dissolution studies.