Raddeanoside R13 Inhibits Proliferation, Invasion, and Metastasis of Gastric Cancer Cells Based on Network Pharmacology and Experimental Validation
R13 inhibited the proliferation, invasion, and metastasis of GC cells while in-ducing apoptosis. Furthermore, R13 may suppress the EMT process in GC cells by inhibit-ing the PI3K/Akt/mTOR signaling pathway. These findings provide a foundation for the potential use of R13 as a therapeutic strategy for gastric cancer.
Authors
- Mingxu Da (ORCID: https://orcid.org/0000-0001-9181-6088)
- Qiong Wu
- Tiantian Zhao (ORCID: https://orcid.org/0000-0003-2700-5314)
- Chenglou Zhu (ORCID: https://orcid.org/0000-0002-9787-7436)
Institutions
- Gansu University of Traditional Chinese Medicine (CN)
- Gansu Provincial Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Current Cancer Drug Targets
- Published
- 2025-06-02
- DOI
- https://doi.org/10.2174/0115680096379893250523102125
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.00