Metal-Free Electrophilic Phosphination with Soft Carbon Nucleophiles: Access to Diverse β-Ketophosphine Oxides
A metal-free electrophilic phosphination protocol utilizing silyl enol ethers as soft carbon nucleophiles has been developed under Tf<sub>2</sub>O/DMSO-mediated conditions. This approach enables convenient access to a diverse range of β-ketophosphine oxides under mild reaction conditions. The broad substrate scope, scalability, and potential for further synthetic applications highlight the practical utility of this method. The development of this method also expands the scope of the umpolung electrophilic phosphination strategies.
Authors
- Yong Xin (ORCID: https://orcid.org/0000-0002-5956-464X)
- Dawei Shi (ORCID: https://orcid.org/0000-0002-3480-7502)
- Bin Yang (ORCID: https://orcid.org/0000-0001-5794-4991)
- Ming Li (ORCID: https://orcid.org/0000-0002-2207-0873)
- Zhichao Wang (ORCID: https://orcid.org/0000-0002-4237-5084)
- Jie Liu (ORCID: https://orcid.org/0000-0002-9685-5825)
- Junru Liu (ORCID: https://orcid.org/0000-0001-7108-4860)
- Shang‐Dong Yang (ORCID: https://orcid.org/0000-0002-4486-800X)
Institutions
- Yantai University (CN)
- State Key Laboratory of Applied Organic Chemistry
- Lanzhou University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1021/acs.joc.5c00437
- Citations
- 1
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- National Natural Science Foundation of China