Evaluation of antigen agnostic anti-tumor activity and immune memory induced by CBX-15 (alphalex <sup>TM</sup> -MMAE) in the rat
CBX-15 eradicates tumors by a combination of both direct cytotoxic action of MMAE as well as through the induction of ICD, the latter of which results in long term anti-tumor immunological memory. To our knowledge, this is the first work demonstrating both anti-tumor efficacy and induction of long-term anti-tumor immune memory by a tumor-selective drug in the rat, the species used for preclinical toxicological evaluation. This study provides a strong justification for exploring combination therapies with CBX-15 and other immunomodulators.
Authors
- Laurie Tylaska
- Connor J. Hagen (ORCID: https://orcid.org/0009-0000-2649-6284)
- Sophia Gayle (ORCID: https://orcid.org/0000-0003-3644-0756)
- Timothy Paradis
- Theresa Pasqualini
- Vishwas Paralkar (ORCID: https://orcid.org/0000-0003-2852-6533)
- Qing Zhang (ORCID: https://orcid.org/0000-0002-2655-4971)
Institutions
- Melinta Therapeutics (United States) (US)
Publication Details
- Journal
- Immunotherapy
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1080/1750743x.2025.2510189
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00