Comparison of the Metabolomic Profile of Cerebrospinal Fluid and Blood Plasma of Patients with Relapsing-Remitting Multiple Sclerosis

INTRODUCTION. Multiple sclerosis is a chronic demyelinating neurodegenerative disease of the central nervous system of autoimmune origin. Molecular processes associated with the onset and progression of multiple sclerosis, as well as its etiology, have not been sufficiently studied. The profile of final and intermediate metabolic products (metabolome) is a reflection of metabolic processes that can shed light on the pathophysiological basis of multiple sclerosis and improve the diagnostic and therapeutic aspects of clinical practice. AIM. Evaluation of the profile of low-molecular metabolites of cerebrospinal fluid and blood plasma in patients with relapsingremitting multiple sclerosis using liquid chromatography with mass spectrometric detection. MATERIALS AND METHODS. The study included 16 patients suffering from various subtypes of multiple sclerosis. Blood plasma and cerebrospinal fluid were collected from the patients for metabolomic analysis. RESULTS AND DISCUSSION. 24 metabolites were identified that allow reliable differentiation between the stages of relapsingremitting multiple sclerosis. The metabolites combined into profiles reflect the predominant involvement of the proinflammatory link during exacerbation of relapsing-remitting multiple sclerosis, and the remyelination link during remission. CONCLUSION. The obtained metabolite profiles indicate differences in the prevailing pathophysiological processes, and individual metabolites can be used as markers of the activity of the inflammatory process of multiple sclerosis.