The Effects of BlooMax Administration on Sperm Quality in Infertile Men: A Double-Blind Randomized Clinical Trial

Background: Infertility is a serious health issue worldwide, affecting approximately 8% - 10% of couples globally. Although various antioxidants and vitamins have been explored to improve fertility potential and semen parameters in infertile patients, the findings have been inconsistent. Objectives: We investigated the effects of BlooMax administration on sperm quality in infertile men in Bandar Abbas during 2023. Methods: This double-blind (patient-researcher) clinical trial was conducted on 100 infertile men aged 18 - 45, with no history of surgery, who were referred to fertility and urology clinics in the city of Bandar Abbas. After applying the inclusion criteria, the intervention group received BlooMax (n = 50) (3 tablets daily-single dose), and the control group (n = 50) received a placebo using block randomization for three months. Mean sperm count, motility, and Morphology Index of two semen analyses (before and after supplement therapy) were compared between the two groups. For statistical analysis, SPSS software version 19 was utilized, and study groups were compared using the Mann-Whitney U, chi-square, and independent samples t-tests. Results: In this study, all participants completed the intervention. The analysis of sperm quality parameters revealed a significant elevation in the concentration of total sperm count per ejaculate in the intervention group following BlooMax administration, rising from 23 million to 30 million (P = 0.001). Progressively motile sperm increased, while non-progressively motile and immotile sperm significantly decreased (both P = 0.001). The number of normal sperms also significantly increased from 2.2 million to 3.2 million (P = 0.001). Conclusions: Comparison of sperm parameters before and after the intervention demonstrated that the consumption of the supplement BlooMax significantly improved sperm quality and reduced infertility due to sperm defects. Limitations of this study included the limited sample size and the inability to assess DNA damage.