Identification of compounds to promote diabetic wound healing based on transcriptome signature
This study highlights the altered expression profiles associated with delayed diabetic wound healing, including reduced inflammation and collagen production. Further drug screening identified compound CG-930 as a novel therapeutic agent with significant potential to promote wound healing in diabetic conditions.
Authors
- Zeyu Yang (ORCID: https://orcid.org/0000-0001-6128-6063)
- Guanhua Du (ORCID: https://orcid.org/0000-0002-6896-0847)
- Jiamin Shang
- Meidai Liang
- Xing-Lan Ye
- Zijie Yin
- Zhaoyu Liu
- Xiuying Yang (ORCID: https://orcid.org/0000-0001-8500-3128)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Beijing Tsinghua Chang Gung Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-02
- DOI
- https://doi.org/10.3389/fphar.2025.1576056
- Citations
- 2
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.05
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality
- Chinese Academy of Medical Sciences