Uso de fitoestrogenios no controle reprodutivo da cães não domiciliados

Stray dogs represent a public health problem in large cities, both due to the zoonotic diseases they transmit and the injuries they cause. The high economic investment in treatment and eradication does not provide stable results, so low-cost auxiliary methods are required to control their reproduction. Our objective was to evaluate the potential use of coumestrol to alter the ovarian and hormonal characteristics of orally treated adult female dogs. Eight adult mixed-breed dogs were used, 3 of which were treated in a single dose with the vehicle (5 μl of DMSO) and the remaining 5 with the phytoestrogen (40 μg in 5 μl of DMSO) in a 2-g kibble of commercial food. The estrous cycle was monitored by cytology of exfoliative vaginal swabs and variations in circulating progesterone for 12 months. At the end of treatment, the ovaries were removed for histopathological evaluation. These data indicate that Coumestrol-treated bitches have altered exfoliative vaginal cytology, reflecting a rupture between follicular and endometrial maturation, as well as differences in Progesterone synthesis regulation.