Pericytes in castration-resistant prostate cancer associated with disease progression and immunotherapy response: insights from single-cell analysis
Our investigation uncovers a CRPC-pericytes subpopulation implicated in cancer progression and immunosuppression, suggesting that therapies targeting the phenotypic transition of pericytes could act synergistically with immunotherapeutic regimens to improve survival rates in CRPC.
Authors
- Qi Hou (ORCID: https://orcid.org/0000-0002-4597-7013)
- Jiahe Liu
- Zhitong Bing (ORCID: https://orcid.org/0000-0002-6302-8612)
- Shigeo Horie (ORCID: https://orcid.org/0000-0002-8612-8368)
- Kai Sun
- Yuhan Wang (ORCID: https://orcid.org/0009-0000-6015-2426)
- Yifeng Qiu (ORCID: https://orcid.org/0009-0005-2028-2863)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Shenzhen University (CN)
- Juntendo University (JP)
- Chinese University of Hong Kong, Shenzhen (CN)
- Shenzhen University Health Science Center (CN)
- Shenzhen Third People’s Hospital (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1186/s12935-025-03838-3
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National Natural Science Foundation of China
- Shenzhen International Cooperation Research Project