Population Cellular Kinetics of Idecabtagene Vicleucel in Patients with Triple-Class–Exposed Relapsed/Refractory Multiple Myeloma
The cellular kinetics of ide-cel can be adequately described by the modified piecewise model. No clinically meaningful covariate effects on cellular kinetics were identified from this modeling study. The population CK model suggests that higher cell expansion rate and lower elimination rates of effector and memory cells were observed in patients with longer progression-free survival.
Authors
- Madhan Masilamani (ORCID: https://orcid.org/0000-0001-8181-8848)
- Xirong Zheng
- Fan Wu (ORCID: https://orcid.org/0000-0001-8339-4049)
- Andrea Caia
- Jian Zhou (ORCID: https://orcid.org/0000-0002-0749-1354)
- Mark Cook (ORCID: https://orcid.org/0000-0001-8647-9208)
- Yiming Cheng (ORCID: https://orcid.org/0000-0001-5428-9418)
- Manisha Lamba
- Julia Piasecki
Institutions
- Bristol-Myers Squibb (Germany) (DE)
- Bristol-Myers Squibb (United States) (US)
- Bristol-Myers Squibb (France) (FR)
- Bristol-Myers Squibb (Sweden) (SE)
- Bristol-Myers Squibb (Switzerland) (CH)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1007/s40262-025-01531-2
- Citations
- 5
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 5.23
Funders
- Bristol-Myers Squibb