Fecal microbiota transplantation from Helicobacter pylori carriers following bismuth quadruple therapy exacerbates alcohol-related liver disease in mice via LPS-induced activation of hepatic TLR4/NF-κB/NLRP3 signaling
BQT markedly alters the gut microbiota in H. pylori carriers, promoting dysbiosis that exacerbates ALD in mice via LPS-mediated activation of hepatic inflammatory pathways. These findings highlight the need for careful consideration of BQT use in ALD patients.
Authors
- Dasheng Xia (ORCID: https://orcid.org/0000-0003-2862-7887)
- Donghang Li (ORCID: https://orcid.org/0000-0002-2607-7968)
- Yi Luo (ORCID: https://orcid.org/0000-0001-7707-708X)
- Daqing Mao (ORCID: https://orcid.org/0000-0003-0313-0129)
- Youren Yu (ORCID: https://orcid.org/0009-0002-6870-5173)
- Lu Xing (ORCID: https://orcid.org/0000-0003-1895-2416)
- Huihui Gao (ORCID: https://orcid.org/0000-0002-3443-438X)
- Su Y (ORCID: https://orcid.org/0000-0002-7695-8878)
- Hui Fang (ORCID: https://orcid.org/0009-0003-1904-787X)
- Yuting Gao (ORCID: https://orcid.org/0000-0001-7590-5670)
- Hongwei Bai (ORCID: https://orcid.org/0009-0003-6623-7414)
Institutions
- Nanjing University of Information Science and Technology (CN)
- Nankai University (CN)
- Tianjin First Center Hospital (CN)
- Tianjin Third Central Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1186/s12967-025-06573-5
- Citations
- 6
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 12.04
Funders
- Tianjin Municipal Health Commission
- National Natural Science Foundation of China
- Natural Science Foundation of Tianjin City