Epigenetic Aging in Pediatric-Onset Multiple Sclerosis
We observed greater point estimates of epigenetic age in participants with POMS compared with healthy controls in all epigenetic clocks tested. This difference was statistically significant for the Hannum and PhenoAge clocks after multivariable modeling. These results are consistent with those of studies in adult MS and suggest that accelerated aging may be present even in the youngest people living with MS.
Authors
- Aaron W. Abrams (ORCID: https://orcid.org/0000-0002-4607-5740)
- Jan-Mendelt Tillema (ORCID: https://orcid.org/0000-0001-6933-8913)
- Defne Yilmaz (ORCID: https://orcid.org/0009-0009-0083-4797)
- Mark Gorman (ORCID: https://orcid.org/0000-0003-3694-8832)
- Lauren Krupp (ORCID: https://orcid.org/0000-0001-7003-807X)
- Jonathan A. Race (ORCID: https://orcid.org/0000-0001-9423-5131)
- Amy Tara Waldman (ORCID: https://orcid.org/0000-0002-1054-0815)
- Leslie A. Benson (ORCID: https://orcid.org/0000-0002-1680-4834)
- Emmanuelle L. Waubant (ORCID: https://orcid.org/0000-0001-5188-0157)
- Ashley Fair
- Jayne Ness (ORCID: https://orcid.org/0000-0001-8017-0138)
- Yolanda Wheeler (ORCID: https://orcid.org/0000-0003-1391-4496)
- John W. Rose (ORCID: https://orcid.org/0000-0003-2382-5921)
- Moses Rodriguez (ORCID: https://orcid.org/0000-0001-6328-6497)
- Teri Schreiner (ORCID: https://orcid.org/0000-0002-3816-812X)
- Tanuja Chitnis (ORCID: https://orcid.org/0000-0002-9897-4422)
- Jennifer S. Graves (ORCID: https://orcid.org/0000-0003-1539-1940)
- Gregory Scott Aaen (ORCID: https://orcid.org/0000-0002-0408-2053)
- Soe Mar (ORCID: https://orcid.org/0000-0001-8449-2003)
- Mary R. Rensel (ORCID: https://orcid.org/0000-0001-9613-8394)
- Stacy J. Caillier (ORCID: https://orcid.org/0000-0002-0218-2077)
- Timothy E. Lotze (ORCID: https://orcid.org/0009-0003-2898-1963)
- Allison Schuette (ORCID: https://orcid.org/0000-0003-0968-0340)
- Lisa F. Barcellos (ORCID: https://orcid.org/0000-0002-0303-3479)
- Christopher Goyne
- Theron Charles Casper (ORCID: https://orcid.org/0000-0001-7512-1294)
Institutions
- Brigham and Women's Hospital (US)
- Cleveland Clinic (US)
- Harvard University (US)
- Washington University in St. Louis (US)
- University of Utah (US)
- Loma Linda University (US)
- University of Alabama at Birmingham (US)
- University of California San Diego (US)
- Mayo Clinic in Arizona (US)
- Multiple Sclerosis Center Of Northeastern New York (US)
- Texas Children's Hospital (US)
- Berkeley Public Health Division (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1212/wnl.0000000000213673
- Citations
- 5
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 4.03