Alterations in Cortical Microstructure, Morphology, and Intrinsic Local Function in Spiking Tissue in Patients With Focal Epilepsy
In a modest sample, spiking regions contained more marked alterations in microstructure and morphology than the remaining cortex. There were nevertheless broader network effects, which may relate to a cascading of structural changes to connected cortices. These results underscore the utility of combining quantitative MRI and EEG for characterizing epileptogenic tissue and assessing network effects.
Authors
- Boris C. Bernhardt (ORCID: https://orcid.org/0000-0001-9256-6041)
- Ella Sahlas (ORCID: https://orcid.org/0000-0002-7119-977X)
- Tamir Avigdor (ORCID: https://orcid.org/0000-0003-1283-7978)
- Raúl Rodríguez‐Cruces (ORCID: https://orcid.org/0000-0002-2917-1212)
- Judy Chen (ORCID: https://orcid.org/0009-0004-6332-9935)
- Jessica Royer (ORCID: https://orcid.org/0000-0002-4448-8998)
- Birgit Frauscher (ORCID: https://orcid.org/0000-0001-6064-1529)
- Jack Lam (ORCID: https://orcid.org/0000-0003-3173-7665)
- Sara Larivière (ORCID: https://orcid.org/0000-0001-5701-1307)
- Neda Bernasconi (ORCID: https://orcid.org/0000-0002-8947-9518)
- Raluca Pana (ORCID: https://orcid.org/0000-0003-2590-1983)
- Yezhou Wang (ORCID: https://orcid.org/0000-0003-3650-5476)
- Andrea Bernasconi (ORCID: https://orcid.org/0000-0001-9358-5703)
- Thaera Arafat (ORCID: https://orcid.org/0000-0002-9210-2092)
- Alexander Ngo (ORCID: https://orcid.org/0000-0002-8999-9388)
- Ke Xie (ORCID: https://orcid.org/0000-0002-7101-2493)
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Université de Sherbrooke (CA)
- Duke University (US)
- McGill University (CA)
- Pratt Institute (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1212/wnl.0000000000213733
- Citations
- 1
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47