New linear bromopyrrole-imidazolidine alkaloids from the Formosan sponge <i>Agelas nakamurai</i>
Chemical investigation of the natural products from Formosan sponge <i>Agelas nakamurai</i> led to the isolation of two undescribed bromopyrrole-imidazolidine alkaloids, nakamudines A and B. The structures of the compounds were determined by extensive spectroscopic analyses, including 2D NMR correlations, while their relative configurations were resolved <i>via</i> NOESY correlation analysis. The alkaloids were assigned as rare linear bromopyrrole alkaloidal epimers possessing an 2,4-imidazolidinedione (hydantoin) moiety. The cytotoxicity and antibacterial activity of these alkaloids were assessed, however, they did not exhibit significant activity in the bioassays conducted.
Authors
- Hui‐Chun Wang (ORCID: https://orcid.org/0000-0003-1414-1595)
- Atallah F. Ahmed (ORCID: https://orcid.org/0000-0003-1224-8428)
- Ping‐Jyun Sung (ORCID: https://orcid.org/0000-0002-6644-9236)
- Jyh‐Horng Sheu (ORCID: https://orcid.org/0000-0002-1216-5991)
- Chung‐Wei Fu (ORCID: https://orcid.org/0000-0003-3113-1073)
- Shu-Fen Chiou
- You-Cheng Lin
Institutions
- Fu Jen Catholic University (TW)
- National Sun Yat-sen University (TW)
- Kaohsiung Medical University (TW)
- China Medical University (TW)
- King Saud University (SA)
- National Museum of Marine Biology and Aquarium (TW)
- China Medical University Hospital (TW)
- Pharmaceutical Biotechnology (Czechia) (CZ)
- China Medical University (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1080/14786419.2025.2513038
- Primary Topic
- Marine Sponges and Natural Products
- Type
- article
- Field-Weighted Citation Impact
- 0.00