Effects of sake lees intake on fecal uremic toxins, plasma D-alanine, constipation, and gut microbiome in healthy adults: A single-arm clinical trial
Sake lees intake may reduce fecal uremic toxins, elevate plasma D-alanine levels, alleviate constipation, and modify the gut microbiome. However, future studies are needed to confirm these effects in patients with CKD.
Authors
- Yasunori Iwata (ORCID: https://orcid.org/0000-0002-4756-5207)
- Yusuke Nakade (ORCID: https://orcid.org/0000-0002-0094-359X)
- Taro Miyagawa (ORCID: https://orcid.org/0000-0003-0186-7362)
- Masashi Mita (ORCID: https://orcid.org/0000-0002-9379-6006)
- Megumi Oshima (ORCID: https://orcid.org/0000-0002-4108-5229)
- Hisayuki Ogura (ORCID: https://orcid.org/0000-0001-9004-3837)
- Takashi Wada
- Shiori Nakagawa (ORCID: https://orcid.org/0000-0001-6774-7959)
- Toshiaki Tokumaru (ORCID: https://orcid.org/0009-0006-5323-0688)
- Norihiko Sakai (ORCID: https://orcid.org/0000-0001-7245-9716)
- Miho Shimizu (ORCID: https://orcid.org/0000-0002-7737-935X)
- Shinji Kitajima (ORCID: https://orcid.org/0000-0002-6532-6496)
- Akinori Hara (ORCID: https://orcid.org/0000-0002-0399-1474)
- Tadashi Toyama (ORCID: https://orcid.org/0000-0003-0162-6286)
Institutions
- Kanazawa University (JP)
- University of Fukui (JP)
- Kanazawa University Hospital (JP)
- Kagami Crystal (Japan) (JP)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1371/journal.pone.0325482
- Primary Topic
- Amino Acid Enzymes and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development